Everything you want
to know.

Mira One is a comprehensive preventive health assessment that combines advanced blood biomarker testing, whole exome genomic sequencing, and pharmacogenomics into a single, integrated report. It's designed to give you a complete picture of your health — before problems appear.

Not at all. The majority of Mira One customers are healthy, motivated adults who want to understand their risks before any problem appears. Prevention and early awareness are exactly what Mira One is designed for.

Your DNA never changes — so the genomic and pharmacogenomics components are a once-in-a-lifetime test. Your blood biomarkers reflect your health today, and we recommend re-testing those annually. We offer an annual biomarker refresh at a significant discount for existing customers. More details on the annual biomarker refresh coming soon.

Mira One is for adults who take their health seriously and want to be proactive. It's particularly valuable for people over 35, those with a family history of chronic disease, and anyone who wants a complete baseline understanding of their health before symptoms develop.

After payment, you complete a health assessment form, schedule your Personalized Pre-Test Genetic Counselling with our clinician, and book a home blood draw. Your sample is sent for both biomarker and genomic analysis. Results are reviewed by our specialist team and compiled into your Mira One report — typically within 45 days of your blood draw.

Approximately 45 days from the date your blood sample is collected. This covers laboratory processing, genomic sequencing, specialist review, and report preparation. We'll notify you as soon as your report is ready.

Before your blood draw, your Personalized Pre-Test Genetic Counselling gives you a dedicated session with one of our genetic counsellors. This is a chance to ask questions, understand what the tests cover, and ensure you're well prepared. It's included in the price of Mira One.

Yes. From a single blood sample, we run the full biomarker panel and extract your DNA for genomic analysis. The home blood draw is simple, quick, and handled by a trained professional who comes to you.

Yes, an overnight fast of 10–12 hours is required before your blood draw to ensure accurate readings for metabolic and lipid markers. You may drink plain water. Our team will confirm the fasting requirements when you schedule your appointment.

A trained phlebotomist from our partner GenePath Diagnostics visits your home or office at your chosen time. The draw takes about 10 minutes. Your sample is then transported to the laboratory under controlled conditions.

The home blood draw is currently available in Pune. We're expanding to other cities soon — if you're outside Pune, please get in touch and we'll let you know when we're available in your area.

Yes, your blood test can be done at home or at any other location of your choosing.

Yes, you can reschedule your blood collection appointment up to 24 hours prior to your original appointment. Use your original booking link or invite to select a new time.

We recommend a 10–12 hour overnight fast before your blood sample collection, as some of the parameters tested require a fasting value. You may drink plain water during this time. Please avoid all food, tea, coffee, and any other beverages.

Aim to get a restful sleep the night before the test. Avoid a heavy or late-night dinner. Stay well hydrated. A rested body helps ensure more reliable results.

Avoid any exercise for at least 8–12 hours before your test, as it may affect certain of your parameters.

If you have a fever, infection, or are menstruating, please inform our team. We will guide you on whether to proceed with or reschedule the test for more accurate results.

The process is quick and usually takes 5–10 minutes.

You may feel the needle prick for a few seconds; most people find it very manageable.

Apply gentle pressure on the site for a few minutes. Avoid lifting heavy objects for a few hours. Drink fluids and rest if needed.

Yes, it is completely safe. Your sample will be collected by a trained professional using sterile, single-use equipment.

Since this is a comprehensive panel, samples are taken in multiple tubes.

Some people feel lightheaded for a brief moment but there are no lasting effects. If you feel giddy, inform the technician immediately and sit or lie down for a few minutes.

Yes, you can resume your regular meals immediately after the test.

Please do NOT take any of your non-essential medications during your 10 to 12 hour fast or on the morning of your test before your sample is collected. Essential medications, such as those for blood pressure, heart conditions, or thyroid issues, can typically be taken with a small sip of water; however, please consult your doctor to confirm if you are unsure.

Yes, take your medications as per your usual routine.

Yes, a urine sample of ~30ml is required as part of the Mira One comprehensive assessment. We will provide you with a sterile container for easy and hygienic collection. Your sample does not need to be the first urine of the day; it can be collected at the time of your blood sample collection.

It is generally not recommended, as it may affect results.

Your reports will be shared with you via email about 6 weeks after your blood test.

Whole exome sequencing analyses the protein-coding regions of your genome — the parts most strongly linked to health outcomes. It identifies genetic variants that may affect your risk for hereditary conditions and how your body responds to certain medications.

Pharmacogenomics studies how your genes affect your response to medications. Your Mira One report includes insights on which common drugs may be more or less effective for you, helping you and your doctor make more informed prescribing decisions.

You wouldn't need to. The genomic and pharmacogenomics components are a once-in-a-lifetime analysis. Only your annual blood biomarker panel would be repeated — your DNA results carry forward permanently.

WES is a genomic test that sequences all of the protein-coding regions of your DNA. These specific sections, called genes, provide the instructions your body needs to grow and function. Think of it like a library of books, where WES reads only the specific pages that contain the actual "recipes" for building your body, rather than reading every single page in every book.

The exome is the collective set of all exons in your genome. Exons are the pieces of DNA that are physically translated into proteins. During the natural process of making a protein, the non-coding parts (introns) are removed, leaving only the exome to do the work. To visualize this, imagine an unedited film — the exons are the actual scenes that make the final movie, while the introns are the deleted scenes that are cut out before the movie is shown.

WES analyzes approximately 20,000 genes. Because every person has these genes, the test is looking for specific variants (changes) within those genes that might be causing a health issue. It's similar to checking 20,000 standard instruction manuals to see if yours has a specific printing error that makes the instructions hard to follow.

WES sequences about 1% to 1.5% of your total genome. Although it is a small percentage, this portion is responsible for about 85% of known disease-causing mutations. This is much like a professional editor focusing only on the dialogue of a script because that is where the most critical plot points are found, even if it's only a small part of the total paperwork.

Focusing on the exome is highly efficient and cost-effective. Since the majority of severe genetic diseases (~85%) originate in these protein-coding regions, it allows doctors to find answers without the massive cost and data noise associated with sequencing the entire 3 billion letters of your DNA. It is the genetic equivalent of searching for a needle in a small, organised sewing kit rather than searching through a massive, disorganised haystack.

WES targets only the 1–2% of DNA that codes for proteins, making it faster and more affordable. In contrast, WGS examines 100% of your DNA, including the non-coding regulatory regions that act like switches to turn genes on or off. Essentially, WES reads the recipes, while WGS reads the recipes plus all the notes in the margins of the cookbook.

WES is more powerful when a diagnosis is unknown because it looks at all 20,000 genes at once. A targeted panel only looks at a small group of genes. If a targeted panel is like looking only at the "Desserts" section of a cookbook, WES is like having the entire cookbook at your disposal when you aren't even sure if the dish you're making is a dessert or a main course.

WES can identify mutations for over 7,000 genetic diseases, including developmental delays, epilepsy, and hereditary risks for cancer. It acts as a wide-lens camera, capturing a broad picture of your genetic health rather than a narrow shot of just one area.

It is ideal for patients with rare or undiagnosed symptoms, or children with unexplained developmental delays. It serves as a final investigative tool for those who have spent years on a diagnostic odyssey, much like a master detective being called in after the local police have exhausted all their leads.

WES generates thousands of variants (DNA changes), and scientists use your medical symptoms and family history as a map to filter them. Without this history, it's like trying to find one specific misspelled word in a library without knowing the title or subject of the book you are looking for.

Yes, WES can identify carrier status, where you carry one copy of a mutated gene. While you remain healthy, this information is vital because it reveals if there is a hidden trait that could be paired with a partner's DNA to affect your future children.

Standard turnaround is 4 to 6 weeks. While this feels like a long time, the process involves complex computer filtering and human expert review.

Your results will be Positive, Negative, or Uncertain. A Positive result is a clear confirmation, a Negative result means the variant was not found, and an Uncertain result requires more time and research. Our counsellors are trained to interpret and explain these results to you.

This is a positive result, meaning a DNA change was found that is a known cause of a disorder. In medical terms, this is the confirmation that explains exactly why a certain health condition is occurring.

A VUS means a DNA change was found, but there isn't enough scientific data to prove if it is harmful or harmless. Scientists see something, but need more evidence before they can determine whether it is a cause for concern.

No. Clinical guidelines state that a VUS should not change your medical management. Doctors won't make a major course correction until more evidence is available through further research.

As more people are tested, a VUS may be upgraded or downgraded. Science is constantly evolving — re-analysing your data every 2 to 3 years may eventually provide the answer you've been waiting for.

No, it just means the test did not find a known variant in the portion analysed. The cause could be in regions of your DNA that haven't been mapped yet, or in a gene that science hasn't yet linked to a specific disease.

Because you share DNA, your result is a family affair. A positive result for you acts as a signal for your relatives, giving them the chance to seek preventative care before they experience the same symptoms.

Not always. Many conditions have incomplete penetrance, where you have the genetic predisposition for a disease but never develop it because of your lifestyle or environment.

WES may miss variants in the non-coding regions or large-scale DNA rearrangements. It is designed to find small changes, but it might miss it if a large section of the instruction manual is missing or rearranged entirely.

No. For large missing chunks of DNA, other tests like Microarrays are more appropriate. WES is like looking for a single typo in a sentence, whereas a Microarray is like weighing the whole book to see if half the pages are missing.

This can occur if the mutation is in a region that the sequencing machine cannot read well. Some parts of our DNA are like a foggy road at night — even the best equipment can't see through everything perfectly.

If the mutation is known, a targeted test is usually better. However, WES can still be useful as a broader scan of your genes to ensure there aren't other hidden risks that the family was previously unaware of.

A pharmacogenetic test (also known as a PGx test) analyses how your DNA affects your response to specific medications. The Mira One test analyses 21 specific genes: ABCG2, CACNA1S, CFTR, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A5, CYP4F2, DPYD, G6PD, HLA-A, HLA-B, IFNL3, NAT2, NUDT15, RYR1, SLCO1B1, TPMT, UGT1A1, and VKORC1.

The test provides insights into your response to 101 medications across 10 therapeutic categories including cardiovascular, psychiatry, oncology, pain, anaesthesia, infectious diseases, neurology, pulmonary, transplant, and gastroenterology.

No. This is a targeted test focusing only on genes related to drug metabolism, not all diseases or health conditions.

The test uses Next Generation Sequencing (NGS) for accurate genetic analysis.

Only medications with strong, evidence-based genetic guidelines as identified by the CPIC (Clinical Pharmacogenetics Implementation Consortium) are included. These are the international gold standard for translating genetic test results into actionable medical prescriptions.

No. They are not included because they are dosed based on blood levels, not genetic metabolism.

No. It evaluates only genetic factors, not interactions between medications.

A normal metabolizer means your body breaks down and clears a medication at the expected rate intended by the manufacturer. While "normal" sounds ideal, it doesn't guarantee a drug will work perfectly — other variables like your age, weight, liver health, or other medications can still influence how you respond.

It means you process some drugs slightly slower than average, which may require monitoring or minor dose adjustments.

It means your body processes certain drugs very slowly, increasing the risk of side effects or toxicity.

It means your body processes some drugs very quickly, which may reduce effectiveness or increase risk depending on the drug.

This means there is insufficient scientific evidence to predict how your body processes that specific drug.

A prodrug is a medication that becomes active only after being processed by your body.

The medication may not work effectively for you because your body cannot activate it properly.

No. The Mira One report is not a prescription. It provides important personalised information that will help you have a focused, purposeful discussion with your doctor. Always consult your doctor before making any changes to your medications.

Your primary care or treating clinician should make all medication-related decisions using the information contained in the Mira One report alongside their assessment of your health.

No. Many factors including age, lifestyle, organ function, and other medications also affect outcomes.

It can identify your genetic risk for certain severe reactions, but cannot predict all allergies.

Yes. It can help guide safer use of anaesthesia and identify certain genetic risks before a procedure.

No. It focuses only on known, clinically actionable genetic variants.

Your genes remain the same, but scientific interpretations may evolve as new research provides additional insights.

No. This assessment does not diagnose disease. It only evaluates how your body processes medications.